各位大神，原研资料里面描述如下。片的原料应该进行了微粉处理。

Control of critical manufacturing steps is achieved through established operating parameters critical to
the finished product (mixing 1, milling, mixing 2, granulation, sizing, lubrication, tableting and coating)
meeting its final product specifications. The respective parameter settings and proven acceptance ranges
(PARs) were selected based upon the results of studies.

疑点1：mixing 1之后才milling，是原料和辅料一起粉碎吗？

疑点2：制粒granulation之后的sizing, lubrication,是什么操作？制粒方式是什么？如果是湿法制粒那么，能不能看出来是流化床制粒还是湿法制粒机制粒？

非常感谢！

mixing之后来个milling通常情况下适用于低剂量药物，就是原料和辅料一起混合之后采用整粒机过一遍，用来促进分散的均匀性。

后面的就是常见的制粒和整粒、混合了，应该是湿法制粒。